CBD Oil Absorption

CBDISTILLERY

Buy CBD Oil Online

A recent study by researchers affiliated with Colorado State University has found that water-soluble cannabidiol products provide the best absorption of CBD, shedding new light on best practices for consumers seeking the benefits of the popular cannabinoid. CBD absorption refers to the transfer of CBD from the point of administration to the bloodstream, where it is transported throughout our body to interact with our cannabinoid receptors. How CBD is absorbed, and how long it stays in our body will determine the effectiveness of a CBD product.

New Study Suggests Water-Soluble Cannabidiol Products Provide Best CBD Absorption

A recent study by researchers affiliated with Colorado State University has found that water-soluble cannabidiol products provide the best absorption of CBD, shedding new light on best practices for consumers seeking the benefits of the popular cannabinoid. The study, which was published last month in the peer-reviewed journal Nutrients, also explored the effects that cannabidiol has on digestion and determined that CBD products are best consumed with food for maximum absorption, among other findings.

The research, which was conducted in conjunction with Colorado State University’s Department of Health and Exercise Science, compared the absorption of five different CBD formulations in 14 male test subjects. Products studied included CBD diluted in medium-chain triglycerides (MCT) coconut oil, CBD isolate, and three different water-soluble CBD ingredients. The goal of the study was to document how each of these formulations of CBD entered and left the bloodstream and at what rate. Additionally, the study profiled how the formulations interacted with liver functionality and if there was evidence that food intake and metabolism were affected by the products.

New research shows that taking water-soluble cannabidiol products with food provided the best . [+] absorption of CBD.

Water-Soluble CBD Had Best Absorption

The study found that water-soluble CBD preparations displayed superior pharmacokinetics compared to oil-based CBD. One of the water-soluble CBD preparations used in the study was created using proprietary technology from NextEvo Naturals, which has proven to significantly improve bioavailability. John McDonagh, CEO of the company, said that the research sheds new light on how consumers can get the most out of the CBD products they take.

“While the potential health benefits of CBD have been widely publicized, this new data suggests consumers should be very aware of the pharmacokinetic differences between commercial CBD formulations, for example, how the CBD you are taking gets absorbed into the body,” McDonagh said in a statement from NextEvo. “We set out to prove that our product formulations may actually be able to offer the many benefits of CBD because they enter the bloodstream quickly and efficiently.”

See also  CBD Oil On Feet For Sleep

The results of the study, which NextEvo notes have not been evaluated by the U.S. Food and Drug Administration, show a more than 500% variance in maximum blood concentration achieved between water-soluble CBD ingredients compared to oil-based formulations and unformulated CBD isolate. The variance represents a significant difference in the body’s ability to absorb and process CBD, which is necessary to reap the potential health and wellness benefits of the cannabinoid.

Best Travel Insurance Companies

Best Covid-19 Travel Insurance Plans

Taking CBD With Food Increases Absorption

The results also showed that consuming water-soluble CBD with food greatly increases the body’s absorption of CBD and modifies early insulin and triglyceride responses. Six hours after consumption, CBD concentration in the bloodstream was three times higher when consumed with food compared to taking the product after fasting. David Chernoff, MD, chief medical officer at NextEvo, says that the research revealed CBD’s potential positive effect on insulin and triglyceride levels.

“Our study results show that within 30 minutes after eating a meal, CBD appeared to lower insulin and triglyceride levels. The exact mechanism of how CBD impacts insulin levels and triglyceride levels is unclear as the CBD levels 30 min post-meal are very low,” Chernoff writes in an email. “What one can infer from these findings is that CBD may have a favorable effect on how fats and sugars are metabolized after a meal so CBD might be beneficial for supporting healthy glucose and lipid metabolism.”

Researchers have long debated if eating a meal or fasting could affect CBD’s absorption into the bloodstream. Some have found that it helps to eat when taking oil-soluble CBD, but the new research suggests that taking water-soluble CBD products with food will provide the most benefit.

“We’ve found that the best way for consumers to take CBD is in a product containing a water-soluble formulation with a meal. This allows the body the opportunity for maximum absorption into the bloodstream,” writes Chernoff. “The more CBD the body absorbs, the more likely the consumer is to experience CBD’s potential benefits.”

CBD is available in a variety of product formulations.

“This is one of the first studies to examine the potential benefits CBD has on digestion and whether it should be administered with food,” NextEvo wrote in a statement about the research. “The study provides significant evidence that consuming CBD with food alters the dynamics of CBD metabolism and increases systemic availability, favorably modifying early insulin and triglyceride responses.”

See also  2000 Mg CBD Gummies

The research also revealed new evidence on the safety of CBD. The study showed that CBD taken at average doses, in this case, 30mg per dose, does not evoke physiologically relevant changes in markers of liver function, suggesting that CBD probably does not represent a risk to the liver.

Potential limitations of the study identified by the researchers include a small sample size and the fact that all test subjects were male, although the authors wrote that they “have no reason to suspect the potential for sex differences.”

A report on the study, “Cannabidiol and Cannabidiol Metabolites: Pharmacokinetics, Interaction with Food, and Influence on Liver Function,” was published online by the journal Nutrients in May.

CBD Effects and How the Body Processes CBD Oil

CBD absorption refers to the transfer of CBD from the point of administration to the bloodstream, where it is transported throughout our body to interact with our cannabinoid receptors, CB1 & CBD1 and non-cannabinoid receptors like our serotonin receptor.

How CBD is absorbed depends on how it is administered and how it is consumed. This will in part determine how effective CBD will be.

What is CBD?

CBD is the abbreviation of cannabidiol and is found in hemp plants. There are over 120 known cannabinoids, and each play a role in our endocannabinoid system. The two most popular cannabinoids are, tretrahydrocannabinol (THC) & CBD. Unlike THC, CBD is non-psychoactive and will not get you high.

In November 2017, the World Health Organization published a report listing all of the potential therapeutic benefits of CBD. Amongst them are; stress and anxiety relief, alleviating pain, limiting inflammation, improving sleep, reducing nausea. For the full list, click here.

How Does the Body Process and Absorbs CBD?

There are 3 main absorption methods; sublingual / oral, smoking / vaping, and topical. They each have a different way of being absorbed and processed by our body, and have different levels of effectiveness.

1) Sublingual and Oral Absorption are the most common way of taking CBD. Think, CBD oils, capsules, edibles or any other food products infused with CBD.

When ingested, CBD goes through the digestive system and to our stomach. From there, it enters the hepatic portal system where CBD is carried to our liver. The liver metabolizes the CBD molecules in what is referred to as the “first-pass effect” to then go into the bloodstream.

See also  Cannaverde CBD Oil

Taking CBD edibles might not be the most effective way of taking CBD because the first-pass effect, effectively prevents the absorption of cannabinoids into the blood. This is why CBD gummies have the lowest percentage of CBD bioavailability. Sometimes even after waiting more than an hour after ingestion, you might feel nothing. For example, if you take a 10mg edible and gummies have a 20% bioavailability , it means that only 2mg of CBD will actually reach your bloodstream, which makes taking that gummy pretty ineffective. On the positive side, research has shown that despite their low bioavailability , CBD edibles produces effects that may last longer.

For CBD drops or tinctures, studies have found that consuming CBD oil with fatty acids can help bypass first-pass metabolism, and therefore increase bioavailability and how much CBD is absorbed. Taking CBD oil sublingually and holding it under your tongue for several seconds before swallowing, allows the mucus membrane of the mouth to absorb CBD, and bypass the digestive system. This is why CBD drops have a high bioavailability, and are more effective than CBD edibles.

2) Smoking and Vaping Absorption

Inhaling CBD is one the quickest ways for CBD to be absorbed, and offers fast relief. When using a CBD vape pen or pre-roll, the compounds are absorbed through the alveoli in the lungs, which offers a large absorptive surface area. It bypasses the first-pass metabolism in a similar way as sublingual administration except that it reaches the bloodstream faster.

A key difference is that while inhaling CBD offers a faster relief than sublingual or oral absorption, the effects wear off a lot quicker. If you are suffering from acute conditions, and need immediate relief, using this method of CBD absorption is great.

3) Topical Absorption

CBD topical products are designed to provide targeted relief to a specific area. The skin has several cannabinoid receptors that absorb and interact with CBD when it is applied to the surface. With a topical application, CBD never reaches the bloodstream as human skin in general has low permeability, which means it blocks most substances from entering. This means that CBD topical application has a low absorption rate so, use CBD lotions, salves, and balms generously.

To read about how to dose CBD oil properly, click here

If you have any questions, reach out to: [email protected]

How useful was this post?

Click on a star to rate it!

Average rating 3 / 5. Vote count: 1

No votes so far! Be the first to rate this post.