CBD Oil For Crohn’s

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In small studies, smoking cannabis (marijuana — the dried parts of the cannabis plant) has improved IBD symptoms, including pain, nausea, and decreased appetite. However, there is currently no evidence that medical cannabis can reduce IBD inflammation or improve disease activity. Further research is needed, and underway now, regarding the impact of cannabis on IBD. Combined THC and CBD Drops for Treatment of Crohn’s Disease There are many reports about efficacy of Cannabis in Crohn’s disease but no controlled trials. The aim of the proposed trial is to

Medical Cannabis

In small studies, smoking cannabis (marijuana — the dried parts of the cannabis plant) has improved IBD symptoms, including pain, nausea, and decreased appetite.

However, there is currently no evidence that medical cannabis can reduce IBD inflammation or improve disease activity. Further research is needed, and underway now, regarding the impact of cannabis on IBD.

Video Length 00:01:20

What is the role of medical cannabis in the management of IBD? You may be hearing more and more about medical cannabis. How can it help patients with IBD? Watch this video to learn more about cannabis as well as its potential benefits and risks.

Therapeutic uses

Cannabis is composed of over 70 active compounds called phytocannabinoids or cannabinoids.

The first is delta-9-tetrahydrocannabinol, or THC. THC is most known for its effects on one’s mental state. It has been known to alleviate nausea and chronic pain and improve one’s appetite.

The second is cannabidiol, or CBD, which has more anti-inflammatory or immune properties. Therapeutic uses may include reducing inflammation and treating insomnia, sleep apnea, spasticity, and pain.

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Potential side effects

It is important to remember that cannabis can cause side effects including severe nausea and vomiting (a condition called cannabis hyperemesis syndrome), impaired short-term memory, difficulty concentrating, altered judgment, impaired coordination, anxiety, worsening mood, and long-term problems with behavior and reasoning, particularly in adolescents. There are also increased risks for fetuses and newborns if used during pregnancy or breastfeeding.

Combined THC and CBD Drops for Treatment of Crohn’s Disease

There are many reports about efficacy of Cannabis in Crohn’s disease but no controlled trials. The aim of the proposed trial is to investigate the efficacy of oil containing the cannabinoids THC and CBD given by mouth for induction of remission in Crohn’s disease.

Condition or disease Intervention/treatment Phase
Crohn’s Disease Drug: THC 5mg/ml and CBS 50mg/ml Drug: Placebo Phase 1 Phase 2

The investigators have recently published a retrospective observational study about the beneficial effect of cannabis in Crohn’s disease. The investigators have also concluded a double blind placebo controlled study of Inhaled cannabis in the treatment of Crohn’s disease. Both studies have shown significant symptomatic improvement of disease. However, objective parameters of inflammation were not measured. The question arises as to whether the observed improvement is merely symptomatic or due to a real change in inflammation. In addition, administration per os is a healthier option than smoking but the efficacy of oral cannabis was not investigated.

The aim of the proposed study in to evaluate the efficacy of drops of cannabis oil in crohn’s disease patients compared to placebo. Treatment success will be defined as a decrease of at least 100 points in CDAI after 8 weeks of treatment.

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