They were charged with multiple drug offences, including cultivating a large commercial quantity of cannabis, as well as diverting electricity.
"The level of sophistication with respect to the secret underground room at the Greenwith property and the manner in which the grow rooms were set up at the Port Wakefield property highlights the extent to which individuals and groups will go to in an effort to avoid detection," Detective Chief Inspector Darren Fielke said.
They said a number of racks, apparently previously used for drying harvested cannabis, were also seized.
Police said the discovery was made as officers searched separate properties at Greenwith and Port Wakefield on Sunday, as part of an investigation into the "the activities of a group involved in the trafficking and cultivation of cannabis".
Police said $135,000 cash was also found hidden within the Greenwith premises, and that electricity had been diverted at the property.
"Those members of the community who engage in this criminal activity do so at their own risk and need to be aware that police are continually conducting investigations and operations to target this activity."
Another 99 cannabis plants were allegedly found in five separate grow rooms at the Port Wakefield property.
They allegedly found a "hidden" doorway, which could only be opened electronically, behind a bookshelf inside the Greenwith property in Adelaide's north-east.
Police said about 65 cannabis plants were found behind the doorway, in what appeared to be a "nursery-style set-up".
In addition it is also important to consider that sometimes the people working in the ‘farms’ are victims of human trafficking and working against their will.
Cannabis farms are very dangerous places and pose a serious risk of fire. Often the electricity meter has been bypassed and seriously overloaded electrical circuits run close to water-filled pipes. Plants grown upstairs in a building can also cause floorboards to rot, presenting the danger of collapse.
Criminals are using more inventive ways to conceal cannabis grows – not just in rooms, but in the back of shops and even underground.
Every cannabis farm we destroy helps prevent a vicious circle. The plants won’t end up as street deals, the profits won’t go on to fund other crime, and they won’t ruin lives or pollute our communities.