Cannabinoid Science Jazz, through our world-leading GW Cannabinoid Platform, is the leader in cannabinoid science, and we passionately believe in the therapeutic and breakthrough potential of GW Pharmaceuticals is undertaking a major research programme in the UK to develop and market distinct cannabis-based prescription medicines [THC:CBD, High THC, High CBD] in a range of medical conditions. The cannabis for this programme is grown in a secret location in the UK. It is expected that the …
Jazz, through our world-leading GW Cannabinoid Platform, is the leader in cannabinoid science, and we passionately believe in the therapeutic and breakthrough potential of cannabis-based medicines to revolutionize how patients deal with their often-overlooked diseases and redefine what living with their disease means.
The world has only recently started to recognize the true potential of cannabinoid science to bring FDA-approved medicines to patients in a new frontier of medicine. Cannabinoids interact with many neurotransmitter and neuromodulator systems in the human body, offering the potential to meet currently unmet needs of patients in multiple treatment areas. Through our GW Cannabinoid Platform and research into endocannabinoids, Jazz is particularly well-positioned at exploring cannabinoid-based therapeutic prospects.
At Jazz, we seek solutions for rare or complex diseases, and work to make those solutions available to the often-overlooked patients who need them. In 2021, we acquired GW Pharmaceuticals and integrated two teams with a shared vision of developing innovative and differentiated therapies that advance science and caring about patients with often-overlooked diseases.
As a leader in cannabinoid science and the first and only company to receive a U.S. Food and Drug Administration (FDA) approval for a plant-derived cannabinoid medicine, GW Pharmaceuticals brings a deep scientific understanding of the pharmacological effects, unique formulation, rigorous clinical testing and regulated manufacturing process of this growing treatment category.
We are building an even stronger company together and look forward to the greater impact we will continue to drive for patients, caregivers, health care providers, and other stakeholders in the cannabinoid space.
Jazz’s existing early-stage research into endocannabinoid therapies, combined with the world-leading GW Cannabinoid Platform, has expanded and diversified our commercial portfolio and growing neuroscience pipeline into several therapeutic areas. To learn more about Jazz’s neuroscience pipeline, please visit here.
GW Cannabinoid Platform
Cannabinoid science has opened the door to the development of FDA-approved plant-derived cannabinoid medications that are used to treat a number of neurological diseases. Over more than two decades, GW Pharmaceuticals, now a part of Jazz Pharmaceuticals, established a world-leading cannabinoid science platform to develop a deep, innovative pipeline of early and late-stage cannabinoid product candidates and highly specialized growing and manufacturing expertise.
Through these committed efforts, GW developed and commercialized the world’s first prescription medicine derived from the cannabis plant. Unlike non-FDA-approved cannabidiol products or cannabis-derived products, GW’s regulatory-approved portfolio ensures that every product manufactured has a safety and efficacy profile that has been thoroughly evaluated in clinical trials, independently peer-reviewed, approved by regulatory authorities (FDA, MHRA, etc.), and consistently manufactured to ensure the highest quality standards are met. To learn more about the difference between FDA-approved and non-FDA-approved cannabinoid products, please visit https://www.cannabinoideducation360.com/ ™ .
Building on GW’s success as a pioneer in this emerging treatment area, Jazz continues to trailblaze to enable the development, manufacture, and commercialization of regulatory approved plant-derived cannabinoid medicines with the potential to transform the lives of patients and their families. To learn more about international cannabinoid science, please visit cannabinoidclinical.com ℠ .
Cannabis-based medicines–GW pharmaceuticals: high CBD, high THC, medicinal cannabis–GW pharmaceuticals, THC:CBD
GW Pharmaceuticals is undertaking a major research programme in the UK to develop and market distinct cannabis-based prescription medicines [THC:CBD, High THC, High CBD] in a range of medical conditions. The cannabis for this programme is grown in a secret location in the UK. It is expected that the product will be marketed in the US in late 2003. GW’s cannabis-based products include selected phytocannabinoids from cannabis plants, including D9 tetrahydrocannabinol (THC) and cannabidiol (CBD). The company is investigating their use in three delivery systems, including sublingual spray, sublingual tablet and inhaled (but not smoked) dosage forms. The technology is protected by patent applications. Four different formulations are currently being investigated, including High THC, THC:CBD (narrow ratio), THC:CBD (broad ratio) and High CBD. GW is also developing a specialist security technology that will be incorporated in all its drug delivery systems. This technology allows for the recording and remote monitoring of patient usage to prevent any potential abuse of its cannabis-based medicines. GW plans to enter into agreements with other companies following phase III development, to secure the best commercialisation terms for its cannabis-based medicines. In June 2003, GW announced that exclusive commercialisation rights for the drug in the UK had been licensed to Bayer AG. The drug will be marketed under the Sativex brand name. This agreement also provides Bayer with an option to expand their license to include the European Union and certain world markets. GW was granted a clinical trial exemption certificate by the Medicines Control Agency to conduct clinical studies with cannabis-based medicines in the UK. The exemption includes investigations in the relief of pain of neurological origin and defects of neurological function in the following indications: multiple sclerosis (MS), spinal cord injury, peripheral nerve injury, central nervous system damage, neuroinvasive cancer, dystonias, cerebral vascular accident and spina bifida, as well as for the relief of pain and inflammation in rheumatoid arthritis and also pain relief in brachial plexus injury. The UK Government stated that it would be willing to amend the Misuse of Drugs Act 1971 to permit the introduction of a cannabis-based medicine. GW stated in its 2002 Annual Report that it was currently conducting five phase III trials of its cannabis derivatives, including a double-blind, placebo-controlled trial with a sublingual spray containing High THC in more than 100 patients with cancer pain in the UK. Also included is a phase III trial of THC:CBD (narrow ratio) being conducted in patients with severe pain due to brachial plexus injury, as are two more phase III trials of THC:CBD (narrow ratio) targeting spasticity and bladder dysfunction in multiple sclerosis patients. Another phase III trial of THC:CBD (narrow ratio) in patients with spinal cord injury is also being conducted. Results from the trials are expected during 2003. Three additional trials are also in the early stages of planning. These trials include a phase I trial of THC:CBD (broad ratio) in patients with inflammatory bowel disease, a phase I trial of High CBD in patients with psychotic disorders such as schizophrenia, and a preclinical trial of High CBD in various CNS disorders (including epilepsy, stroke and head injury). GW Pharmaceuticals submitted an application for approval of cannabis-based medicines to UK regulatory authorities in March 2003. Originally GW hoped to market cannabis-based prescription medicines by 2004, but is now planning for a launch in the UK towards the end of 2003. Several trials for GW’s cannabis derivatives have also been completed, including four randomised, double-blind, placebo-controlled phase III clinical trials conducted in the UK. The trials were initiated by GW in April 2002, to investigate the use of a sublingual spray containing THC:CBD (narrow ratio) in the following medical conditions: pain in spinal cord injury, pain and sleep in MS and spinal cord injury, neuropathic pain in MS and general neuropathic pain (presented as allodynia). Results from these trials show that THC:CBD (narrow ratio) caused statistically significant reductions in neuropathic pain in patients with MS and other conditions. In addition, improvements in other MS symptoms were observed as well. Phase II studies of THC:CBD (narrow ratio) have also been completed in patients with MS, spinal cord injury, neuropathic pain and a small number of patients with peripheral neuropathy secondary to diabetes mellitus or AIDS. A phase II trial of THC:CBD (broad ratio) has also been completed in a small number of patients with rheumatoid arthritis, as has a trial of High CBD in patients with neurogenic symptoms. A phase II trial has also been evaluated with High THC in small numbers of patients for the treatment of perioperative pain. The phase II trials provided positive results and confirmed an excellent safety profile for cannabis-based medicines. GW Pharmaceuticals received an IND approval to commence phase II clinical trials in Canada in patients with chronic pain, multiple sclerosis and spinal cord injury in 2002. Following meetings with the US FDA, Drug Enforcement Agency (DEA), the Office for National Drug Control Policy, and National Institute for Drug Abuse, GW was granted an import license from the DEA and has imported its first cannabis extracts into the US. Preclinical research with these extracts in the US is ongoing.
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